Effects of chronic stress on <i>nectin1</i> levels in the mouse primary somatosensory cortex

Chronic exposure to stressful experiences impairs synaptic plasticity. Previous studies have shown that the spine densities of pyramidal neurons, turnover mushroom-type spines, and excitatory–inhibitory balance in primary somatosensory cortex (S1) are modulated by stress. Trans-synaptic cell adhesion molecules (CAMs) implicated stress-induced deficits. However, it remains unknown whether stress dysregulates CAMs S1 thereby In this study, we applied early-life (ELS), chronic social defeat (CSDS), restraint paradigms measured mRNA levels nectin1 wild-type conditional forebrain corticotropin-releasing hormone receptor 1 type (CRHR1) knockout mice. We found ELS increased adult but not adolescent Moreover, CSDS mice via CRH-CRHR1 system. Our findings suggest is vulnerable repeated exposures at some life stages, dysregulated expression may underlie structural functional abnormalities S1.